Job Description

Job Description

Well-funded biotech in SSF seeks a Computational Chemistry Director or Associate Director with experience in CADD- and structure-based design for lead optimization of small molecules to advance the pipeline of innovative therapeutics toward the clinic.

**Onsite in South San Francisco Monday through Friday (5 days/week)**

Highlights :

• Reports to SVP, Discovery
• Potential to have one or more direct reports
• Two lead targets: CNS oncology + neurodegeneration
• Financial runway forecasted through Spring 2027
• ~25 full-time employees

Responsibilities :

• Provide strategic leadership and hands-on execution of our CADD efforts
• Collaborate closely with chemists and biologists on virtual screening, hit identification and structure-based design
• Guide the optimization of drug candidates that induce protein degradation
• Use machine-learning (ML) to build in silica models to predict DMPK properties
• Perform and automate high throughput molecular dynamics simulations to predict protein function and protein-ligand binding
• Utilize established tools and design new methods/tools
• Scientific programming as needed

Required Qualifications:

• PhD in Computational Chemistry or related discipline
• 7+ years of relevant experience in drug discovery
• Computer aided drug design (CADD) /structure- and ligand-based design for small molecules
• Dotmatics, Schrodinger, MOE, OpenEye, or Gaussian software
• QSAR, QSPR, and conformational analysis
• Molecular mechanics and dynamics simulations

Preferred Skills & Knowledge:

• Understanding of in vitro and in vivo DMPK principles
• Artificial Intelligence/Machine Learning (AI/ML) approaches to predictive modeling
• Quantum mechanics methods
• Statistical design of experiments (DoE)
• Multiparameter optimization
• Experimental assay methods and technology for protein-ligand interactions
• Programming with languages such as perl, python, or C++
• Cheminformatics / database algorithms
• Emerging drug modalities such as covalent inhibitors, bifunctionals, molecular glues and/or PROTACs

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